Stereoselective antifibrillogenic peptides and peptidomimetics thereof
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United States of America Patent
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Jun 13, 2006
Grant Date -
N/A
app pub date -
May 4, 2000
filing date -
May 5, 1999
priority date (Note) -
Expired
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Abstract
The present invention relates to antifibrillogenic agents for inhibiting amyloidosis and/or for cytoprotection for the treatment amyloidosis disorders. These agents include peptides, isomers thereof and peptidomimetic compounds thereof. These agents comprise peptide having a sequence identified from the glycosaminoglycan (GAG) binding region and the prot--prot interaction region of the amylo protein. The peptide has at least one [D] amino acid isomer substitution. The invention also relates to the peptide bound to a label for vivo imaging of amyloid deposits.
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