Quinoline derivatives process of synthesis and medicaments containing these derivatives
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United States of America Patent
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Jun 20, 2006
Grant Date -
Dec 23, 2004
app pub date -
Oct 14, 2002
filing date -
Oct 12, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to derivatives corresponding to formula I: ##STR00001## in which X is an alkyl-(CH.sub.2).sub.n-- chain with n=0, 1 or 2, or O or N, Z is an aromatic which may contain heteroatoms chosen from O, N or S, as substitutions for the carbon atoms constituting said aromatic ring, this ring being substituted or otherwise with Rb, Rb represents 1 to 3 substituents chosen from --OH, --OR, --COOH, --COOR, --COH, --COR, --NH.sub.2, --NH(R), --NH(R,R'), --SH, --SR and CN, Ra is H or --(CH.sub.2).sub.n'--Y, with n'=0, 1, 2 or 3 and Y and --CH.sub.3, --COOH, --COOR, --CN, --OH, --OR, SR, or an aryl group optionally substituted with Rb, R and R' represent a linear or branched alkyl chain of 1 to 4 C, and their pharmaceutically acceptable salts. Application as active ingredient of medicaments inhibiting retrovirus integrases.
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