Compositions and methods for systemic inhibition of cartilage degradation
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United States of America Patent
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Jun 27, 2006
Grant Date -
Dec 25, 2003
app pub date -
Jan 31, 2003
filing date -
Oct 20, 1998
priority date (Note) -
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Abstract
Methods and compositions for inhibiting articular cartilage degradation. The compositions preferably include multiple chondroprotective agents, including at least one agent that promotes cartilage anabolic activity and at least one agent that inhibits cartilage catabolism. The compositions may also include one or more pain and inflammation inhibitory agents. The compositions may be administered systemically, such as to treat patients at risk of cartilage degradation at multiple joints, and suitably may be formulated in a carrier or delivery vehicle that is targeted to the joints. Alternatively the compositions may be injected or infused directly into the joint.
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