Antimitotic eleuthesides
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United States of America Patent
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Jun 27, 2006
Grant Date -
Dec 30, 2004
app pub date -
Jun 25, 2002
filing date -
Jun 22, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for conjugating functional moieties to the eleutherobin pharmacophore without significant loss of antimitotic activity. Moieties that may be conjugated at C-11 include those intended to increase the solubility of the pharmacophore, to facilitate drug formulation, or to facilitate in vivo delivery or targeting.
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