Integrin-binding peptides
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United States of America Patent
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Jun 27, 2006
Grant Date -
Aug 1, 2002
app pub date -
Jul 30, 1999
filing date -
Nov 24, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention is directed to novel integrin binding peptides. These peptides bind to .alpha..sub.v- of .alpha..sub.5-containing integrins and can exhibit high binding affinity. They contain one of the following sequence motifs: RX.sub.1ETX.sub.2WX.sub.3 [SEQ ID NO:1] (especially RRETAWA [SEQ ID NO:8]); RGDGX [SEQ ID NO:2], in which X is an amino acid with a hydrophobic, aromatic side chain; the double cyclic CX.sub.1CRGDCX.sub.2C [SEQ ID NO:15]; and RLD. The peptides generally exhibit their highest binding affinity when they assume a conformationally stabilized configuration. This invention also provides methods of using these peptides.
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