US Patent No: 7,070,996

Number of patents in Portfolio can not be more than 2000

Production of cultured human mast cells and basophils for high throughput small molecule drug discovery

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Abstract

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Provided are methods for producing and screening proliferated populations of CD34-negative progenitor cells, mucosal mast cells, connective tissue-type mast cells and basophil cells. The methods generate uniform proliferated populations of cells. The proliferated populations contain a uniform population of a size suitable for use in high throughput screening methods, for example, screening for agents that alter exocytosis. The invention includes screening the proliferated populations with at least one candidate bioactive agent, and evaluating the cells to detect a cell with an altered phenotype. The invention also includes isolating a candidate bioactive agent that causes the altered phenotype. Additionally, cells formed according to the described methods are also encompassed by the invention.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
RIGEL PHARMACEUTICALS, INC.SOUTH SAN FRANCISCO, CA337

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rossi, Alexander B San Francisco, CA 33 1490

Cited Art Landscape

Patent Info (Count) # Cites Year
 
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (1)
6,225,044 Method for gene transfer into cells activated from a quiescent state 4 1999
 
CELLDEX THERAPEUTICS, INC. (3)
5,554,512 Ligands for flt3 receptors 30 1994
5,843,423 Methods of stimulating hematopoietic cells with flt3-ligand 55 1997
6,190,655 Methods of using Flt-3 ligand for exogenous gene transfer 15 1998
 
NORTHWESTERN UNIVERSITY (1)
6,261,841 Compositions, kits, and methods for modulating survival and differentiation of multi-potential hematopoietic progenitor cells 3 2000
 
DANA-FARBER CANCER INSTITUTE, INC. (1)
4,559,310 Assay methods and systems utilizing mast cell clones 14 1983
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
RIGEL PHARMACEUTICALS, INC. (18)
7,557,210 2,4-pyrimidinediamine compounds and their uses 69 2003
* 2004/0029,902 2,4-Pyrimidinediamine compounds and their uses 106 2003
8,178,671 Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds 13 2004
* 2005/0234,049 Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds 117 2004
7,521,560 2-substituted quinoline compounds and their uses 0 2005
7,435,814 2,4-Pyrimidinediamine compounds and their uses 40 2005
7,582,648 Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds 59 2006
* 2008/0312,438 METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISEASES WITH 2,4-PYRIMIDINEDIAMINE COMPOUNDS 43 2006
7,452,879 Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds 61 2006
7,659,280 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases 8 2007
* 2007/0197,782 2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES 64 2007
7,655,797 Intermediates for making 2,4-pyrimidinediamine compounds 35 2008
* 2009/0082,567 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 6 2008
7,803,939 2,4-pyrimidinediamine compounds and their uses 33 2008
* 2009/0171,085 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 3 2008
8,334,296 2,4-pyrimidinediamine compounds and their uses 12 2008
* 2009/0156,622 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES 34 2008
8,314,093 2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases 0 2009
* Cited By Examiner

Maintenance Fees

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11.5 Year Payment $7400.00 $3700.00 $1850.00 Jan 4, 2018
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