Process for the preparation of pseudomonic acid a antibiotic by microbiological method
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United States of America Patent
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Jul 18, 2006
Grant Date -
May 29, 2003
app pub date -
Nov 12, 2002
filing date -
Feb 3, 1999
priority date (Note) -
Expired
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Abstract
A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20.degree. C. and 30.degree. C. containing organic nitrogen and carbon sources and, optionally, mineral salts.
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Patent Owner(s)
Patent Owner | Address | |
---|---|---|
TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYTARSASAG | PALAGI UT NO 13 DEBRECEN 4042 |
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Albrecht, Karoly | Budapest, HU | 10 | 41 |
Balogh, Gabor | Debrecen, HU | 25 | 60 |
Barta, Istvan | Budapest, HU | 19 | 41 |
Erdei, Janos | Debrecen, HU | 13 | 73 |
Gulyas, Eva | Debrecen, HU | 7 | 5 |
Lang, Ildiko | Budapest, HU | 10 | 27 |
Mozes, Nee Suto Julianna | Budapest, HU | 4 | 9 |
Petroczki, Magdolna | Budapest, HU | 3 | 4 |
Szabo, Istvan M | Budapest, HU | 5 | 15 |
Szell, Valeria | Budapest, HU | 7 | 27 |
Tedges, Aniko | Budapest, HU | 3 | 4 |
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