Process for the preparation of pseudomonic acid a antibiotic by microbiological method
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United States of America Patent
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Jul 18, 2006
Grant Date -
May 29, 2003
app pub date -
Nov 12, 2002
filing date -
Feb 3, 1999
priority date (Note) -
Expired
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Abstract
A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired compound is disclosed. In particular, the procedure of the present invention comprises cultivation of the Pseudomonas sp. bacterium strain No. 19/26 deposited under accession No. NCAIM(P)B 001235 in the National Collection of the Agricultural and Industrial Microorganisms, Budapest, Hungary, or its pseudomonic acid A-producing mutant or variant, on a medium at a temperature of between about 20.degree. C. and 30.degree. C. containing organic nitrogen and carbon sources and, optionally, mineral salts.
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