Biological agent-containing ceramic coating and method
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United States of America Patent
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Aug 8, 2006
Grant Date -
Aug 5, 2004
app pub date -
Jan 31, 2003
filing date -
Jan 31, 2003
priority date (Note) -
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Abstract
The invention provides an implantable article, a method of preparing the same, and methods of modifying a ceramic-coated implantable article. The implantable article comprises a biocompatible substrate and a bioactive ceramic surface coating into which a biological agent is incorporated. The preparation and modification of an implantable article involve incubating a biocompatible substrate surface or pre-existing ceramic coating thereon with a composition comprising (i) a biological agent, (ii) calcium ions, (iii) phosphate ions, and (iv) a liquid carrier.
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