Methods of administering and enhancing absorption of pharmaceutical agents
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United States of America Patent
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Aug 8, 2006
Grant Date -
Aug 21, 2003
app pub date -
Aug 16, 2002
filing date -
Dec 21, 1998
priority date (Note) -
In Force
status (Latency Note)
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Abstract
Pharmaceutical compositions comprising a macromolecular pharmaceutical agent in mixed micellar form are disclosed. The mixed micelles are formed from an alkali metal alkyl sulfate, and at least three different micelle-forming compounds as described in the specification. Micelle size ranges between about 1 and 10 nanometers. Methods for administering the compositions are also disclosed. A preferred method for administering the present composition is through the buccal region of the mouth, which has been demonstrated to achieve peak plasma levels of the pharmaceutical agent in about thirty minutes.
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