External addition of pulses to fluid channels of body to release or suppress endothelial mediators and to determine effectiveness of such intervention
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United States of America Patent
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Aug 15, 2006
Grant Date -
Aug 1, 2002
app pub date -
Sep 28, 2001
filing date -
Sep 28, 2000
priority date (Note) -
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Abstract
Methods of medical treatment and diagnosis using mediators released by endothelial cells stimulated by external addition of pulses to the circulation are disclosed. The external pulses produce circumferential shear stress in body fluid channels that subsequently stimulates the endothelial cells to produce mediators that become available for therapeutic and diagnostic purposes. The preferred means of adding external pulses is the mechanical inducement of periodic acceleration of the body or parts of the body by a reciprocating motion platform.
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