Growth factor which acts through erb b-4 rtk
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United States of America Patent
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Aug 22, 2006
Grant Date -
Jun 24, 2004
app pub date -
Apr 20, 2001
filing date -
Apr 21, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A novel ErbB-4 ligand, referred to herein as Neuregulin-4 (NRG-4) is disclosed as well as polynucleotide sequences encoding NRG-4, oligonucleotides and oligonucleotide analogs derived from polynucleotide sequences, a display library displaying short peptides derived from NRG-4, antibodies recognizing NRG-4, peptides or peptide analogs derived from NRG-4, and pharmaceutical compositions and methods of employing peptides or peptide analogs, oligonucleotides and oligonucleotide analogs, and/or polynucleotide sequences to up-regulate or down-regulate ErbB-4 receptor activity (signaling).
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