Transgenic cells transfected with pituitary tumor transforming gene (PTTG)) expression vectors and uses therefor
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United States of America Patent
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Aug 29, 2006
Grant Date -
May 29, 2003
app pub date -
Oct 4, 2002
filing date -
Nov 21, 1996
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Abstract
Described are cells transfected with expression vectors containing pituitary tumor transfer gene (PTTG) and uses therefor. The PTTG nucleic acids may be operatively linked to a vector, optionally provided with control and expression sequences, and/or may be carried by a host cell. The host cell may be a thyroid stimulating hormone (TSH)-sensitive cell transfected with an expression vector comprising a DNA segment encoding functional PTTG, wherein the cell overexpresses PTTG in response to TSH. Also described is an in vitro cell model used to study biological processes mediated by PTTG and a method for evaluating a compound for its ability to modulate PTTG expression.
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