Antisense oligonucleotide modulation of STAT3 expression
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United States of America Patent
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Aug 29, 2006
Grant Date -
Apr 7, 2005
app pub date -
Feb 6, 2004
filing date -
Apr 8, 1999
priority date (Note) -
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Abstract
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
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