4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
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United States of America Patent
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Aug 29, 2006
Grant Date -
Jun 10, 2004
app pub date -
Mar 24, 2003
filing date -
Mar 25, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides a compound of the formula: ##STR00001## wherein A is selected from N, CH and CR; R is selected from halogen, optionally substituted alkyl, aralkyl and aryl, OH, NH.sub.2, NHR.sup.1, NR.sup.1R.sup.2 and SR.sup.3; R.sup.1, R.sup.2 and R.sup.3 are each optionally substituted alkyl, aralkyl or aryl groups; B is selected from NH.sub.2 and NHR.sup.4; R.sup.4 is an optionally substituted alkyl, aralkyl or aryl group; X is selected from H, OH and halogen; Z is selected from H, Q, SQ and OQ; Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer, a pharmaceutically acceptable salt, an ester, or a prodrug thereof; with the proviso that the stereochemistry of the aza-sugar moiety is D-ribo or 2'-deoxy-D-erythro-; pharmaceutical compositions comprising said compound; and methods of treatment using said compound.
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