Process for preparing and isolating rac-bicalutamide and its intermediates
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United States of America Patent
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Sep 5, 2006
Grant Date -
Mar 4, 2004
app pub date -
Jun 25, 2003
filing date -
Jun 13, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone}]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof. The present invention further discloses a new process for the isolation and purification of racemic and optically active bicalutamide.
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