US Patent No: 7,103,410

Number of patents in Portfolio can not be more than 2000

Apparatus and method for reversal of myocardial remodeling with electrical stimulation

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Abstract

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An apparatus and method for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CARDIAC PACEMAKERS, INC.ST PAUL, MN2936

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
KenKnight, Bruce H Maple Grove, MN 171 7489
Kramer, Andrew P Stillwater, MN 229 7664
Salo, Rodney W Fridley, MN 116 6595
Spinelli, Julio C Shoreview, MN 162 6959

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (3)
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5,174,289 Pacing systems and methods for control of the ventricular activation sequence 238 1990
5,267,560 Methods for control of the ventricular activation sequence 196 1992
 
Intermedics, Inc. (3)
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4,872,459 Pacemaker for detecting and terminating a tachycardia 99 1988
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MARDIL, INC. (1)
2002/0082,647 Cardiac disease treatment and device 76 2000
 
Ceske vysoke uceni technicke (1)
5,058,605 Method and device for the controlled local, non-invasive application of DC pulses to human and animal tissues 104 1990
 
IMPULSE DYNAMICS N.V. (2)
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6,363,279 Electrical muscle controller 127 2000
 
Mirowski; Mieczyslaw (1)
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PFIZER INC. (1)
2002/0115,081 Diagnosis and treatment of cardiovascular conditions 31 2001
 
MEDTRONIC, INC. (11)
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5,233,985 Cardiac pacemaker with operational amplifier output circuit 161 1991
5,156,149 Sensor for detecting cardiac depolarizations particularly adapted for use in a cardiac pacemaker 152 1992
5,370,665 Medical stimulator with multiple operational amplifier output stimulation circuits 196 1993
* 5,507,782 Method and apparatus for dual chamber cardiac pacing 110 1994
5,683,429 Method and apparatus for cardiac pacing to prevent atrial fibrillation 189 1996
5,797,970 System, adaptor and method to provide medical electrical stimulation 173 1996
5,824,019 Pacing system with physiologically timed ventricular pacing 48 1996
5,851,226 Temporary transvenous endocardial lead 70 1996
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Biosense, Inc. (1)
6,066,094 Cardiac electromechanics 108 1998
 
AKAMAI TECHNOLOGIES, INC. (1)
* 2009/0132,648 CONTENT DELIVERY AND GLOBAL TRAFFIC MANAGEMENT NETWORK SYSTEM 60 2009
 
EV Vascular, Inc. (1)
6,556,872 Therapeutic device and method for treating diseases of cardiac muscle 26 2000
 
Cardiac Pacemakers, Inc. (14)
4,674,518 Method and apparatus for measuring ventricular volume 241 1985
5,158,079 Implantable device for preventing tachyarrhythmias 41 1991
5,935,160 Left ventricular access lead for heart failure pacing 202 1997
6,112,117 Method and apparatus for treating cardiac arrhythmia using electrogram features 80 1997
6,152,955 Implantable conformal coil patch electrode with multiple conductive elements for cardioversion and defibrillation 52 1999
6,038,483 Implantable conformal coil patch electrode with multiple conductive elements for cardioversion and defibrillation 41 1999
6,058,329 Optimization of pacing parameters based on measurement of acoustic noise 171 1999
6,151,524 Apparatus and method for treating ventricular tachyarrhythmias 144 1999
6,418,343 Method and apparatus for adjusting the sensing threshold of a cardiac rhythm management device 75 1999
* 6,640,135 Apparatus and method for spatially and temporally distributing cardiac electrical stimulation 34 2000
6,574,506 System and method for timing synchronized pacing 66 2000
6,628,988 Apparatus and method for reversal of myocardial remodeling with electrical stimulation 183 2001
6,973,349 Method and apparatus for minimizing post-infarct ventricular remodeling 67 2001
6,915,160 Dynamically optimized multisite cardiac resynchronization device 61 2002
 
KNISLEY, STEPHEN B. (1)
5,995,871 System and method for cardioversion using scan stimulation 75 1997
 
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (1)
* 6,868,287 Cardiac remodeling 12 2000
 
Pacesetter, Inc. (3)
4,628,934 Method and means of electrode selection for pacemaker with multielectrode leads 186 1984
5,109,842 Implantable tachyarrhythmia control system having a patch electrode with an integrated cardiac activity system 164 1990
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SORIN CRM S.A.S. (3)
5,514,161 Methods and apparatus for controlling atrial stimulation in a double atrial triple chamber cardiac pacemaker 210 1995
5,584,867 Method and apparatus for controlling a double atrial triple chamber cardiac pacemaker having a fallback mode 207 1995
5,995,870 Multi-site cardiac stimulator for the treatment of cardiac insufficiency by stimulation 41 1998
 
Vitatron Medical, B.V. (2)
4,549,548 Pacemaker system with automatic event-programmed switching between unipolar and bipolar operation 154 1983
5,534,016 Dual chamber pacing system and method utilizing detection of ventricular fusion for adjustment of the atrial-ventricular delay as therapy for hypertrophic obstructive cardiomyopathy 132 1995
 
GRAEMED PTY LIMITED (1)
5,674,259 Multi-focal leadless apical cardiac pacemaker 183 1995
 
ABIOMED, INC. (1)
* 6,314,322 System and method for treating dilated cardiomyopathy using end diastolic volume (EDV) sensing 75 1998
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 2009/0254,141 APPARATUS AND METHOD FOR REVERSAL OF MYOCARDIAL REMODELING WITH ELECTRICAL STIMULATION 8 2009
* 2012/0041,505 PRE-EXCITATION PACING FOR TREATMENT OF HYPERTENSION 1 2011
 
Cardiac Pacemakers, Inc. (32)
7,292,887 Apparatus and method for spatially and temporally distributing cardiac electrical stimulation 17 2003
* 2004/0030,357 Apparatus and method for spatially and temporally distributing cardiac electrical stimulation 6 2003
* 7,392,084 Demand-based cardiac function therapy 21 2003
7,572,226 System and method for monitoring autonomic balance and physical activity 12 2003
7,676,259 Dynamically optimized multisite cardiac resynchronization device 7 2005
* 2005/0216,066 Dynamically optimized multisite cardiac resynchronization device 18 2005
7,366,568 Controlled delivery of intermittent stress augmentation pacing for cardioprotective effect 23 2005
* 7,548,782 Method for reversal of myocardial remodeling with electrical stimulation 10 2006
* 2006/0293,716 APPARATUS AND METHOD FOR REVERSAL OF MYOCARDIAL REMODELING WITH ELECTRICAL STIMULATION 9 2006
* 8,046,070 Pre-excitation pacing for treatment of hypertension 3 2006
* 2008/0109,043 PRE-EXCITATION PACING FOR TREATMENT OF HYPERTENSION 13 2006
8,560,067 Apparatus for spatially and temporally distributing cardiac electrical stimulation 0 2007
8,090,442 Apparatus and method for spatially and temporally distributing cardiac electrical stimulation 1 2007
* 2008/0097,541 APPARATUS AND METHOD FOR SPATIALLY AND TEMPORALLY DISTRIBUTING CARDIAC ELECTRICAL STIMULATION 9 2007
* 2008/0097,538 APPARATUS AND METHOD FOR SPATIALLY AND TEMPORALLY DISTRIBUTING CARDIAC ELECTRICAL STIMULATION 8 2007
8,027,723 Controlled delivery of intermittent stress augmentation pacing for cardioprotective effect 6 2008
* 2008/0215,105 CONTROLLED DELIVERY OF INTERMITTENT STRESS AUGMENTATION PACING FOR CARDIOPROTECTIVE EFFECT 13 2008
8,065,003 Demand-based cardiac function therapy 3 2008
7,899,532 Method and apparatus for minimizing post-infarct ventricular remodeling 1 2009
* 8,521,278 Smart delay for intermittent stress therapy 0 2009
* 2009/0281,591 SMART DELAY FOR INTERMITTENT STRESS THERAPY 15 2009
8,046,066 Apparatus for reversal of myocardial remodeling with pre-excitation 3 2009
7,833,164 System and method for monitoring autonomic balance and physical activity 3 2009
8,103,345 Cardiac pacing using adjustable atrio-ventricular delays 3 2010
8,612,001 Method and apparatus for minimizing post-infarct ventricular remodeling 0 2011
8,611,998 Controlled delivery of intermittent stress augmentation pacing for cardioprotective effect 1 2011
8,369,948 Apparatus for reversal of myocardial remodeling with pre-excitation 1 2011
* 8,295,928 Pre-excitation pacing for treatment of hypertension 0 2011
8,551,010 Respiration monitoring for heart failure using implantable device 1 2012
* 8,594,791 Pre-excitation pacing for treatment of hypertension 0 2012
* 2013/0046,355 PRE-EXCITATION PACING FOR TREATMENT OF HYPERTENSION 0 2012
8,634,913 Apparatus for reversal of myocardial remodeling with pre-excitation 0 2013
 
BACKBEAT MEDICAL, INC. (6)
8,086,315 Cardiac stimulation apparatus and method for the control of hypertension 2 2008
* 2009/0018,608 CARDIAC STIMULATION APPARATUS AND METHOD FOR THE CONTROL OF HYPERTENSION 24 2008
8,428,729 Cardiac stimulation apparatus and method for the control of hypertension 2 2011
9,008,769 Methods and systems for lowering blood pressure through reduction of ventricle filling 2 2013
9,320,903 Cardiac stimulation apparatus and method for the control of hypertension 0 2013
9,333,352 Methods and systems for lowering blood pressure through reduction of ventricle filling 0 2015
 
MEDTRONIC, INC. (3)
8,126,549 Cardiac protection system and method 3 2008
8,423,141 Pre-excitation stimulus timing based on mechanical event 0 2009
* 2010/0198,294 PRE-EXCITATION STIMULUS TIMING BASED ON MECHANICAL EVENT 0 2009
* Cited By Examiner

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