Proteinaceous adjuvants
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United States of America Patent
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Sep 12, 2006
Issued Date -
N/A
app pub date -
Jun 8, 1995
filing date -
Jun 10, 1994
priority date (Note) -
Expired
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Abstract
A modulated immune response to an antigen is achieved by coadministering the antigen and a genetically-detoxified pertussis holotoxin, particularly one retaining its immunogenicity, to a host. The modulated immune response enables immunogenic compositions, including multivalent pediatric vaccines such as DTP, to be provided which produce a modulated immune response in the absence of extrinsic adjuvants such as alum. The adjuvanting effect achieved by the genetically-detoxified pertussis holotoxin enables at least the same level of adjuvanting effect to be achieved as previously attained by alum, without the undesirable side effects thereof.
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