Mutant human hepatitis B viral strain and uses thereof
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United States of America Patent
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Sep 12, 2006
Grant Date -
Oct 21, 2004
app pub date -
Jan 20, 2004
filing date -
Jun 19, 1998
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Expired
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Abstract
This invention provides an isolated strain of Hepatitis B virus designated Human Hepatitis B Virus Surface Antigen-`S`-133 Oon Strain (Methionine to Threonine) which constituent viral genome is deposited under Accession Nos. P97121501, P97121502 and P97121503 with the European Collection of Cell Culture on 15.sup.th Dec. 1997. This invention also provides an isolated nucleic acid encoding a polypeptide which is a mutant major surface antigen of a strain of hepatitis B virus, such polypeptide having an amino acid sequence which differs from the amino acid sequence of a major surface antigen of a wild type hepatitis B virus in that the amino acid at position number 133 of such polypeptide is a threonine rather than a methionine. This invention also provides an isolated nucleic acid which encodes a peptide, wherein the peptide is encoded by a nucleic acid molecule comprising nucleotides 527 through 595 of SEQ. I.D. No. 1 and the purified peptide. This invention also provides various methods of using the disclosed isolated nucleic acid and peptides.
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