Polynomial amplification of nucleic acids
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United States of America Patent
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Sep 26, 2006
Grant Date -
Dec 9, 2004
app pub date -
Feb 28, 2003
filing date -
Mar 1, 2002
priority date (Note) -
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Abstract
The invention provides methods and compositions for the amplification and replication of nucleic acid molecules. In particular, novel amplification methods, referred to herein as polynomial amplification, are provided. According to these methods, a nucleic acid molecule to be amplified is contacted with at least two primers; a non-replicable primer which may hybridize to the nucleic acid molecule being amplified, and a replicable primer which may hybridize to a primer extension product generated from extension of the non-replicable primer.
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