Apparatus, systems and related methods for dispensing and /or evaluating dry powders

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7118010
APP PUB NO 20040050860A1
SERIAL NO

10607389

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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Methods, systems, and computer program products flowably dispense meted amounts of dry powders using a flexing piezoelectric layer to transmit a vibratory signal to the dry powder to facilitate fluidic flow through a flow channel. The apparatus for dispensing dry powders can include: (a) an elongate flow channel having a width, length, and depth, the flow channel having axially spaced apart inlet and outlet ports, wherein the elongate flow channel is configured to extend in an angular orientation of between about 10 75 degrees relative to the axial direction of flow; (b) a flexible piezoelectric layer configured to overlie the flow channel so that, in operation, the piezoelectric layer is able to flex upwardly away from the lowermost portion of the underlying flow channel; and (c) a signal generator operatively associated with the piezoelectric layer, wherein, in operation, the signal generator is configured to output a signal for flexing the piezoelectric layer in the elongate flow channel.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ORIEL THERAPEUTICS, INC.DURHAM, NC38

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boekestein, Vanessa Lexington Park, MD 2 44
Crowder, Timothy M Durham, NC 11 308
Hickey, Anthony J Chapel Hill, NC 16 336

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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Other [Check patent profile for assignment information] (5)
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MEDERIO AG (1)
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AISAN KOGYO KABUSHIKI KAISHA (3)
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FISONS PLC (1)
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The United States of America as represented by the Secretary of the Navy (2)
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5957124 Dynamic particle size control for aerosolized drug delivery 182 1995
5694919 Lockout device for controlled release of drug from patient-activated dispenser 210 1995
5915378 Creating an aerosolized formulation of insulin 150 1995
5934272 Device and method of creating aerosolized mist of respiratory drug 275 1995
5960792 Device for aerosolized delivery of peptide drugs 197 1995
6098620 Device for aerosolizing narcotics 80 1995
5660166 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 96 1996
5735263 Lockout device for controlled release of drug from patient-activated dispenser 215 1996
6012450 Intrapulmonary delivery of hematopoietic drug 153 1996
5823178 Disposable package for use in aerosolized delivery of drugs 99 1996
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5743252 Method for releasing controlled amount of aerosol medication 81 1996
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5829436 Ventilation imaging using a fine particle aerosol generator 34 1997
5888477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 69 1997
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5829435 Prefilter for prevention of clogging of a nozzle in the generation of an aerosol and prevention of administration of undesirable particles 59 1997
5910301 Method of intrapulmonary administration of a narcotic drug 54 1997
5826570 Delivery of aerosol medications for inspiration 72 1997
5813397 Delivery of aerosol medication for inspiration 126 1997
5884620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 92 1997
5855564 Aerosol extrusion mechanism 47 1997
5792057 Ventilation imaging using a fine particle aerosol generator 42 1997
6131567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 71 1998
6192882 Formulation and devices for monitoring the efficacy of the delivery of aerosols 52 1998
6085753 Insulin delivery enhanced by coached breathing 38 1998
6123068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 74 1998
5873358 Method of maintaining a diabetic patient's blood glucose level in a desired range 17 1998
5970973 Method of delivering insulin lispro 64 1998
6098615 Method of reproducibly effecting a patient's glucose level 38 1998
6024090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 17 1998
6131570 Temperature controlling device for aerosol drug delivery 211 1998
5941240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 53 1998
5971951 Aerosol extrusion mechanism 80 1998
6014969 Disposable package for use in aerosolized delivery of antibiotics 44 1998
6070575 Aerosol-forming porous membrane with certain pore structure 54 1998
6288360 Excimer laser ablation process control of multilaminate materials 31 1999
6167880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 73 1999
6354516 Pore structures for reduced pressure aerosolization 15 1999
6295986 Reactive ion etching method of fabricating nozzles for aerosolized delivery of therapeutic or diagnostic agents 39 2000
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6230706 Method and device for creating aerosol with porous membrane with certain pore structure 45 2000
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6349719 Formulation and devices for monitoring the efficacy of the delivery of aerosols 32 2001
 
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Consort Medical PLC (1)
6062214 Inhaler for medicament 78 1997
 
BTG INTERNATIONAL LIMITED (1)
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* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
KRAFT FOODS R & D, INC. (1)
* 2011/0183,049 Device And A Process For Continuously Feeding Chocolate Ingredients As Well As A System And A Process For Producing A Chocolate Mass 0 2011
 
ORIEL THERAPEUTICS, INC. (10)
* 7677411 Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders 3 2003
8210171 Tubular dry powder drug containment systems, associated inhalers and methods 3 2005
8327843 Drug containment systems with sticks, related kits, dry powder inhalers and methods 1 2006
* 2009/0165,788 DRUG CONTAINMENT SYSTEMS WITH STICKS, RELATED KITS, DRY POWDER INHALERS AND METHODS 1 2006
8776840 Tubular dry powder feeders with axially applied vibration for dry powder filling systems 1 2011
8720497 Direct fill dry powder systems with dosing heads configured for on/off controlled flow 1 2011
* 2011/0204,083 TUBULAR DRY POWDER FEEDERS WITH AXIALLY APPLIED VIBRATION FOR DRY POWDER FILLING SYSTEMS 1 2011
* 2011/0204,094 DIRECT FILL DRY POWDER SYSTEMS WITH DOSING HEADS CONFIGURED FOR ON/OFF CONTROLLED FLOW 3 2011
9339616 Dry powder inhalers 0 2012
9278767 Direct fill dry powder systems with dosing heads configured for on/off controlled flow 0 2014
 
NORDSON CORPORATION (3)
* 8767214 Powder flow detection 2 2011
* 2013/0088,716 POWDER FLOW DETECTION 1 2011
9372108 Powder flow detection 0 2014
 
TAKAZONO TECHNOLOGY INCORPORATED (6)
* 9561887 Hopper and medicine supply apparatus including the same 0 2011
* 9290318 Hopper and medicine supply apparatus including the same 0 2011
* 2013/0161,355 Hopper and Medicine Supply Apparatus Including the Same 1 2011
* 2013/0161,356 Hopper and Medicine Supply Apparatus Including the Same 0 2011
* 9393179 Medicine supply apparatus 0 2012
* 2014/0239,016 Medicine Supply Apparatus 0 2012
 
SYMYX TECHNOLOGIES EUROPE, S.A. (2)
8118068 Apparatus and methods for storing and dispensing solid material 1 2009
* 2010/0051,644 APPARATUS AND METHODS FOR STORING AND DISPENSING SOLID MATERIAL 0 2009
 
STC.UNM (1)
9492625 Dry powder inhaler with flutter dispersion member 0 2010
 
SYMYX SOLUTIONS, INC. (1)
* 2009/0090,433 Apparatus And Method For Storing And Dispensing Material, Especially In Micro Quantities And In Combination With Limited Starting Amounts 0 2006
 
MICRODOSE THERAPEUTX, INC. (4)
8439033 Inhalation device 3 2008
8991390 Inhalation device and method 0 2011
9132246 Inhalation device 0 2013
9539400 Inhalation device 0 2015
 
FREESLATE, INC. (3)
* 7614429 Apparatus and methods for storing and dispensing solid material 15 2005
* 2007/0006,942 Apparatus and method for storing and dispensing material, especially in micro quantities and in combination with limited starting amounts 8 2005
* 2010/0127,022 DISPENSING VALVE 1 2008
 
NEW JERSEY INSTITUTE OF TECHNOLOGY (2)
* 7806150 Mixing and packing of particles 0 2009
* 2009/0272,078 MIXING AND PACKING OF PARTICLES 0 2009
 
RESPIRA THERAPEUTICS, INC. (2)
8561609 Dry powder inhaler 3 2011
8651104 Bead-containing dry powder inhaler 0 2012
 
GLAXOSMITHKLINE LLC (4)
8252234 Apparatus for producing a pharmaceutical product 0 2005
8122849 Apparatus and method for producing a pharmaceutical product 10 2005
8101244 Apparatus and method for producing or processing a product or sample 2 2005
* 2006/0016,830 Apparatus and method for pharmaceutical production 18 2005
 
MG 2-S.r.l. (1)
* 7694497 Machine and process for filling capsules or similar 5 2005
* Cited By Examiner

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