Splice variant of MyD88 and uses thereof
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United States of America Patent
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Oct 17, 2006
Issued Date -
N/A
app pub date -
Jul 9, 2004
filing date -
Jan 10, 2002
priority date (Note) -
Expired
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Abstract
The present invention relates to the field of infection and inflammation and, more specifically, to the field of pathogen-induced nuclear factor kappa B activation. More specifically, a novel splice variant of MyD88, (MyD88.sub.S), which has been identified encoding a protein that inhibits LPS-induced NF-.kappa.B activation. MyD88.sub.S is a target to inhibit the phenomenon of endotoxin-tolerance that occurs in sepsis.
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