US Patent No: 7,125,689

Number of patents in Portfolio can not be more than 2000

Method for rendering streptokinase less immunogenic to a human

ALSO PUBLISHED AS: 20030153043

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Abstract

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Protein, or parts of proteins, may be rendered non-immunogenic, or less immunogenic, to a given species by identifying in their amino acid sequences one or more potential epitopes for T-cells of the given species and modifying the amino acid sequence to eliminate at least one of the T-cell epitopes. This eliminates or reduces the immunogenicity of the protein when exposed to the immune system of the given species. Monoclonal antibodies and other immunoglobulin-like molecules can particularly benefit from being de-immunised in this way: for example, mouse-derived immunoglobulins can be de-immunised for human therapeutic use.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MERCK PATENT GMBHDARMSTADT2799

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Adair, Fiona Suzanne Aberdeen, GB 5 9
Carr, Francis Joseph Balmedie, GB 32 109
Carter, Graham By Newmachar, GB 35 83
Hamilton, Anita Anne Aberdeen, GB 5 9

Cited Art Landscape

Patent Info (Count) # Cites Year
 
CENTRO DE INMUNOLOGIA MOLECULAR (1)
5,712,120 Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them 39 1995

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
PRECISION BIOLOGICS, INC. (4)
7,314,622 Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers 3 2006
7,829,678 Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers 1 2008
8,535,667 Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers 0 2010
8,524,456 Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers 0 2010
 
NEOGENIX ONCOLOGY, INC. (1)
7,763,720 Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers 1 2007

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