Tissue adhesive sealant
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United States of America Patent
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Oct 31, 2006
Grant Date -
Mar 31, 2005
app pub date -
Jul 20, 2004
filing date -
Jul 23, 2003
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.
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