Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof
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United States of America Patent
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Oct 31, 2006
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N/A
app pub date -
Nov 3, 2000
filing date -
Oct 24, 2000
priority date (Note) -
Expired
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Abstract
The present invention provides hydrophobic heparin conjugates that are soluble in organic solvents but not in water, a method of preparing them, and a method of using them. Particularly, the present invention provides hydrophobic heparin conjugates that are prepared by covalently binding a polymer to heparin and a hydrophobic agent to the polymer. The hydrophobic heparin conjugates of the present invention maintain a good antithrombogenic effect and are insoluble in water due to their hydrophobicity, so they can be effectively used as coating agents for modifying the surfaces of medical devices.
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