US Patent No: 7,135,181

Number of patents in Portfolio can not be more than 2000

Method for down-regulation of amyloid

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Abstract

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A method for in vivo down-regulation of amyloid protein in an animal, including a human being, the method comprising effecting presentation to the animal's immune system of an immunogenically effective amount of at least one amyloidogenic polypeptide or subsequence thereof which has been formulated so that immunization of the animal with the amyloidgenic polypeptide or subsequence thereof induces production of antibodies against the amyloidogenic polypeptide, and/or at least one analogue of the amyloidogenic polypeptide wherein is introduced at least one modification in the amino acid sequence of the amyloidogenic polypeptide which has as a result the immunization of the animal with the analogue induces production of antibodies against the amyloidogenic polypeptide.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
H. LUNDBECK A/SVALBY-COPENHAGEN200

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jensen, Martin Roland Holte, DK 12 97
Nielsen, Klaus Gregorius Soborg, DK 16 196
Rasmussen, Peter Birk Frederiksberg, DK 25 174

Cited Art Landscape

Patent Info (Count) # Cites Year
 
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THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
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Milkhaus Laboratory, Inc. (1)
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JANSSEN ALZHEIMER IMMUNOTHERAPY (3)
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Musashi Engineering Kabushiki Kaisha (1)
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INTELLECT NEUROSCIENCES INC. (1)
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The Scripps Research Institute (2)
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NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
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TRUSTEES OF BOSTON UNIVERSITY (1)
5,200,339 Proteases causing abnormal degradation of amyloid .beta.-protein precursor 41 1991
 
SCHERING-PLOUGH ANIMAL HEALTH CORPORATION (1)
4,608,251 LHRH analogues useful in stimulating anti-LHRH antibodies and vaccines containing such analogues 82 1984
 
Bavarian Nordic A/S (1)
2004/0141,958 Novel methods for therapeutic vaccination 33 2003
 
ALCON RESEARCH, LTD. (1)
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H. Lundbeck A/S (2)
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SCIOS NOVA INC. (1)
5,223,482 Recombinant Alzheimer's protease inhibitory amyloid protein and method of use 31 1989
 
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NEW YORK UNIVERSITY (1)
* 6,713,450 Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid .beta. for induction of an immune response to amyloid .beta. and amyloid deposits 48 2001
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
* 2013/0287,807 COMPOUNDS FOR TREATING SYMPTOMS ASSOCIATED WITH PARKINSON'S DISEASE 0 2013
 
ID BIOMEDICAL CORPORATION OF QUEBEC (1)
* 2006/0229,233 Compositions and methods for treating neurological disorders 9 2005
 
CrossBeta Biosciences B.V. (10)
* 2006/0045,853 Cross-beta structure comprising amyloid-binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity 3 2005
* 2007/0003,552 Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation 8 2005
8,114,832 Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition 0 2005
* 2007/0015,206 Method for detecting and/or removing protien comprising a cross-beta structure from a pharmaceutical composition 4 2005
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8,067,187 Cross-β structure binding compounds 0 2006
* 2008/0207,488 Method for Detecting Peptides Comprising a Cross-B Structure 3 2006
* 2010/0015,126 Methods of Binding of Cross-Beta Structures By Chaperones 3 2007
8,158,585 Cross-β structure comprising amyloid-binding proteins and methods for detection of the cross-β structure, for modulating cross-β structures fiber formation and modulating cross-β structure-mediated toxicity 0 2007
* 2009/0191,228 Immunogenic compositions capable of activating T-cells 4 2008
 
Intezyne Technologies, Inc. (2)
7,618,944 Encapsulated amyloid-beta peptides 20 2008
* 2008/0274,965 ENCAPSULATED AMYLOID-BETA PEPTIDES 5 2008
 
ABBVIE DEUTSCHLAND GMBH & CO. KG (2)
8,895,004 Method for the treatment of amyloidoses 0 2008
9,176,150 Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 0 2011
 
UNIVERSITY OF SOUTH FLORIDA (1)
8,188,046 Amyloid beta peptides and methods of use 0 2007
 
H. Lundbeck A/S (3)
* 2009/0092,579 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 1 2008
8,871,212 Amyloid-beta polypeptide vaccine 0 2008
* 2010/0047,262 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 0 2008
 
ABBVIE INC. (7)
8,691,224 Anti-Aβ globulomer 5F7 antibodies 0 2006
8,497,072 Amyloid-beta globulomer antibodies 0 2006
8,455,626 Aβ conformer selective anti-aβ globulomer monoclonal antibodies 0 2007
8,987,419 Amyloid-beta binding proteins 0 2011
8,877,190 Aβ conformer selective anti-Aβ globulomer monoclonal antibodies 0 2011
9,062,101 Amyloid-beta binding proteins 0 2011
9,359,430 Abeta conformer selective anti-Abeta globulomer monoclonal antibodies 0 2013
 
NEW YORK UNIVERSITY (2)
* 8,685,718 Mucosal immunization to prevent prion infection 0 2004
* 2007/0059,807 Mucosal immunization to prevent prion infection 2 2004
* Cited By Examiner

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