Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
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United States of America Patent
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Nov 28, 2006
Issued Date -
N/A
app pub date -
Aug 28, 2001
filing date -
Jul 30, 1993
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Expired
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Abstract
A gas emulsion forming composition comprising a dry, hollow, particulate, approximately microspherical material permeated with a gas or gas mixture, which upon dissolution in aqueous liquid forms a gas emulsion comprising a plurality of bubbles surrounded by a layer of at least a first and a second surfactant, wherein the first surfactant consists essentially of a phospholipid or mixture of phospholipids having at least one acyl chain which comprises at least 10 carbon atoms, and comprising at least about 5% w/w of total surfactant, and wherein the second surfactant may or may not be a phospholipid and is more water soluble than the first surfactant; kits for preparing such microbubbles; and methods for using such microbubbles as contrast agents.
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