Methods for producing substituted acrylic acid esters and use of the latter for producing substituted .gamma.-amino acids
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United States of America Patent
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Nov 28, 2006
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N/A
app pub date -
Jul 19, 2004
filing date -
Jan 25, 2002
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Abstract
The invention relates to methods for producing substituted acrylic acid esters and to the use of the latter for producing substituted .gamma.-amino acids, such as gabapentin and pregabalin. The substituted acrylic acid esters are produced by Wadsworth-Emmons olefination with trialkyl phosphonoacetate in the presence of alkali carbonate as the base, in an aqueous solvent.
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