Humanized immunoglobulin reactive with .alpha.4.beta.7 integrin
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United States of America Patent
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Dec 12, 2006
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app pub date -
Aug 15, 1996
filing date -
Aug 15, 1996
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Abstract
The present invention relates to humanized immunoglobulins having binding specificity for .alpha.4.beta.7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a portion of an immunoglobulin of human origin (e.g., a human framework region, a human constant region). In one embodiment, the humanized immunoglobulin can compete with murine Act-1 for binding to human .alpha.4.beta.7 integrin. In a preferred embodiment, the antigen binding region of the humanized immunoglobulin comprises each of the complementarity determining regions of the light and heavy chains of the murine Act-1 antibody.
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