Hybrid polyketide synthases and novel loading domains
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United States of America Patent
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Dec 12, 2006
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N/A
app pub date -
Jun 29, 1999
filing date -
Jun 29, 1998
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Expired
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Abstract
A polyketide synthase ('PKS') of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used.
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