Methods for enhancing graft survival by modulating heme oxygenase activity
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United States of America Patent
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Dec 19, 2006
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app pub date -
Feb 18, 2004
filing date -
Dec 17, 1998
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Abstract
Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein. Nucleic acid molecules that modulate heme oxygenase-I activity and therefore find use in the described methods include, for example, molecules that encode a polypeptide that itself exhibits heme oxygenase-I activity or antisense oligonucleotides that act to inhibit heme oxygenase-I activity in a cell.
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