Antimicrobial polymeric surfaces
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United States of America Patent
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Dec 19, 2006
Grant Date -
May 15, 2003
app pub date -
Apr 16, 2002
filing date -
Apr 23, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Bactericidal compositions are disclosed that comprise a polymeric compound immobilized on a material. Medical devices are also disclosed which comprise such a bactericidal composition. Methods are disclosed for covalently derivatizing the surfaces of common materials with an antibacterial polycation, e.g., poly(vinyl-N-pyridinium bromide); the first step of the methods involves coating the surface with a nanolayer of silica. Various commercial synthetic polymers derivatized in this manner are bactericidal, i.e., they kill on contact up to 99% of deposited Gram-positive and Gram-negative bacteria, whether deposited through air or water.
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