Glutamic acid receptor and utilization thereof
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United States of America Patent
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Jan 2, 2007
Grant Date -
Jan 6, 2005
app pub date -
Apr 21, 2004
filing date -
Oct 23, 2001
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Abstract
An agonist or antagonist of glutamic acid or an allosteric modulator is screened by reacting a glutamic acid receptor protein having the following properties with a substance binding thereto in the presence of a test substance and detecting the inhibition or promotion of the reaction:(A) it has a transmembrane domain and an intracellular domain common to those of type 4 metabotropic glutamic acid receptor protein, or(B) it has an extracellular domain by about 316 or 327 amino acid residues shorter than that of the type 4 metabotropic glutamic acid receptor protein.
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