US Patent No: 7,160,544
Number of patents in Portfolio can not be more than 2000
Method of vaccinating vertebrates
Stats
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Jan 9, 2007
Issued date -
Nov 10, 2003
filing date -
10/705,660
serial no -
Expired
status
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Abstract
The invention provides a vaccine composition and a method of preparation including the steps of: forming a water-in-oil emulsion including an alginate in water, an oil, an antigen, and either (a) a cellulose ether and at least one nonionic surfactant or (b) a PEO-PPO-PEO triblock copolymer surfactant and at least one nonionic surfactant; followed by crosslinking the alginate in the emulsion with at least two cations selected from the group consisting of aluminum, barium, calcium, lithium, manganese, strontium, and zinc, to form antigen-containing, crosslinked alginate microparticles; and harvesting the microparticles. Another aspect of the invention is a method of vaccinating a vertebrate species including the step of administering to the species a vaccine composition prepared according to the method of the invention. The compositions of the invention have improved antigen loading, reduced microparticle size, increased hydrophobicity, improved uptake by antigen sampling cells, controlled antigen release characteristics, and improved immunogenicity.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 4,673,566 Microencapsulation of living tissue and cells | 152 | 1984 | |
| 4,689,293 Microencapsulation of living tissue and cells | 100 | 1984 | |
| 4,806,355 Microencapsulation of living tissue and cells | 104 | 1987 | |
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| 4,352,883 Encapsulation of biological material | 407 | 1979 | |
| 4,391,909 Microcapsules containing viable tissue cells | 243 | 1981 | |
| 4,803,168 Microencapsulation with polymers | 74 | 1986 | |
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| 5,352,448 Oral administration of antigens | 26 | 1992 | |
| 5,674,495 Alginate-based vaccine compositions | 18 | 1995 | |
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| 4,808,404 Live vaccine for coccidiosis utilizing coccidial sporozoites | 40 | 1988 | |
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| 4,873,090 Non-adjuvenated vaccine | 12 | 1986 | |
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| 4,792,452 Controlled release formulation | 88 | 1987 | |
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| 6,214,331 Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained | 60 | 1997 | |
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| 5,019,100 Use of a polymer network, method for preparing a prepolymer and also preparation which yields a polymer network after curing | 32 | 1988 | |
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| 4,220,152 Delivery system | 45 | 1979 | |
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| 6,656,470 Vaccine composition, method of preparing the same, and method of vaccinating vertebrates | 3 | 2001 | |
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| 4,780,315 Rumen-stable pellets | 9 | 1985 | |
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| 4,798,786 Living cells encapsulated in crosslinked protein | 89 | 1982 | |
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| 5,075,109 Method of potentiating an immune response | 154 | 1988 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jul 9, 2014 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jul 9, 2018 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |