Anti-sickling agents
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United States of America Patent
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Jan 9, 2007
Grant Date -
Aug 12, 2004
app pub date -
Dec 3, 2003
filing date -
Dec 4, 2002
priority date (Note) -
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Abstract
The provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and non-toxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2-furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.
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