Manufacture of single isomer methylphenidate
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United States of America Patent
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Jan 16, 2007
Grant Date -
Mar 14, 2002
app pub date -
Aug 10, 2001
filing date -
Feb 2, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention pertains to a process for obtaining a single enantiomer, d or l, of threo-methylphenidate, comprising resolution of a mixture of the enantiomers; racemisation of the unwanted enantiomer, to give a mixture of all four stereoisomers; and separation of the erythro stereoisomers, to leave the same mixture of enantiomers for resolution.
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