Bioreactor mediated recellularization of natural and tissue engineered vascular grafts
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United States of America Patent
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Feb 20, 2007
Grant Date -
Nov 27, 2003
app pub date -
Aug 13, 2002
filing date -
Nov 22, 1999
priority date (Note) -
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Abstract
Processes for producing a tissue graft comprising acellularizing or devitalizing a tubular tissue to produce a tissue matrix. The tissue matrix is then populated with at least some viable cells. The processing and the populating steps are performed in a closed system, such as a bioreactor. Tissue grafts produced using the inventive processes may be capable of withstanding physiological stress and strain conditions present at a site into which the tissue graft is implanted.
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