Variant B7 co-stimulatory molecules
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United States of America Patent
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Feb 27, 2007
Grant Date -
Jul 24, 2003
app pub date -
Dec 20, 2001
filing date -
Jun 23, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.
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