US Patent No: 7,185,651
Number of patents in Portfolio can not be more than 2000
Flow regulator for aerosol drug delivery and methods
Stats
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Mar 6, 2007
Issued date -
May 14, 2003
filing date -
10/257,745
serial no -
In Force
status
Importance
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Abstract
An aerosolization device comprises a housing having a mouthpiece, and a flow path arrangement in fluid communication with the mouthpiece. The flow path arrangement has a flow regulating valve and a threshold valve, where the threshold valve is configured to open at a first vacuum level and to close at a second vacuum level that is less than the first vacuum level. The housing includes a region that is adapted to hold a powder in fluid communication with the flow path arrangement so that air drawn through the mouthpiece opens the threshold valve once the first vacuum level is exceeded and remains open until the vacuum falls below the second vacuum level. The flow rate of the air drawn through the mouthpiece is regulated by the flow regulating valve to remain within a certain range while the threshold valve remains open.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 5,333,106 Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers | 98 | 1992 | |
| 5,364,838 Method of administration of insulin | 164 | 1993 | |
| 5,509,404 Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values | 148 | 1994 | |
| 5,419,315 Intrapulmonary delivery of hormones | 59 | 1994 | |
| 5,558,085 Intrapulmonary delivery of peptide drugs | 31 | 1994 | |
| 5,672,581 Method of administration of insulin | 53 | 1994 | |
| 5,884,620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume | 46 | 1997 | |
| 6,085,753 Insulin delivery enhanced by coached breathing | 37 | 1998 | |
| 5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range | 16 | 1998 | |
| 5,941,240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume | 44 | 1998 | |
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| 5,458,135 Method and device for delivering aerosolized medicaments | 192 | 1992 | |
| 5,785,049 Method and apparatus for dispersion of dry powder medicaments | 115 | 1994 | |
| 5,654,007 Methods and system for processing dispersible fine powders | 100 | 1995 | |
| 5,740,794 Apparatus and methods for dispersing dry powder medicaments | 100 | 1995 | |
| 5,586,550 Apparatus and methods for the delivery of therapeutic liquids to the respiratory system | 92 | 1995 | |
| 5,775,320 Method and device for delivering aerosolized medicaments | 94 | 1995 | |
| 5,826,633 Powder filling systems, apparatus and methods | 37 | 1996 | |
| 5,922,354 Methods and system for processing dispersible fine powders | 25 | 1997 | |
| 6,089,228 Apparatus and methods for dispersing dry powder medicaments | 62 | 1998 | |
| 6,606,992 Systems and methods for aerosolizing pharmaceutical formulations | 23 | 2000 | |
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| 2003/0023,649 Digital filtering method and device and sound image localizing device | 1 | 2002 | |
| 2003/0023,649 Digital filtering method and device and sound image localizing device | 1 | 2002 | |
| 2003/0023,649 Digital filtering method and device and sound image localizing device | 1 | 2002 | |
| 2003/0023,649 Digital filtering method and device and sound image localizing device | 1 | 2002 | |
| 2003/0023,649 Digital filtering method and device and sound image localizing device | 1 | 2002 | |
| 2003/0023,649 Digital filtering method and device and sound image localizing device | 1 | 2002 | |
| 2003/0023,649 Digital filtering method and device and sound image localizing device | 1 | 2002 | |
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| 5,622,166 Dry powder inhaler delivery system | 83 | 1995 | |
| 5,692,492 Hand-held inhalation-actuated spray device | 94 | 1995 | |
| 6,006,747 Dry powder inhaler | 30 | 1997 | |
| 6,029,663 Dry powder inhaler delivery system | 41 | 1997 | |
| 6,116,238 Dry powder inhaler | 52 | 1997 | |
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| 5,213,236 Dispensing valve for packaging | 132 | 1991 | |
| 5,339,995 Dispensing valve for packaging | 101 | 1993 | |
| 5,377,877 Dispensing valve for packaging | 93 | 1993 | |
| 5,409,144 Dispensing valve for packaging | 120 | 1993 | |
| 5,439,143 Dispensing valve for packaging | 125 | 1994 | |
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| 5,167,506 Inhalation device training system | 100 | 1991 | |
| 5,408,994 Inhalation device | 47 | 1993 | |
| 5,437,271 Deagglomerators for dry powder inhalers | 50 | 1994 | |
| 6,012,454 Dry powder inhalation device | 40 | 1997 | |
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| 5,826,571 Device for use with metered dose inhalers (MDIS) | 65 | 1996 | |
| 5,692,496 Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament | 18 | 1996 | |
| 5,823,183 Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament | 23 | 1997 | |
| 5,988,163 Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament | 15 | 1998 | |
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| 5,533,505 Disposable inhaler | 34 | 1994 | |
| 5,983,893 Inhalation device | 20 | 1996 | |
| 6,105,574 Single dose inhaler II | 15 | 1998 | |
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| 4,627,432 Devices for administering medicaments to patients | 247 | 1983 | |
| 4,811,731 Devices for administering medicaments to patients | 185 | 1986 | |
| 4,778,054 Pack for administering medicaments to patients | 101 | 1986 | |
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| 4,926,852 Medication delivery system phase one | 141 | 1988 | |
| 5,027,806 Medication delivery system phase two | 80 | 1990 | |
| 5,320,094 Method of administering insulin | 96 | 1992 | |
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| 5,692,498 CPR device having valve for increasing the duration and magnitude of negative intrathoracic pressures | 43 | 1995 | |
| 6,062,219 Apparatus and methods for assisting cardiopulmonary resuscitation | 34 | 1997 | |
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| 5,921,237 Dry powder inhaler | 64 | 1996 | |
| 6,055,980 Dry powder inhaler | 16 | 1998 | |
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| 6,138,673 Inhalation device and method | 18 | 1997 | |
| 6,109,261 Powder inhaler with breath flow regulation valve | 25 | 1998 | |
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| 5,033,655 Dispensing package for fluid products and the like | 108 | 1989 | |
| 4,991,745 Dispensing valve with trampoline-like construction | 72 | 1990 | |
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| 6,029,661 Powder dispenser | 23 | 1995 | |
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| 5,875,776 Dry powder inhaler | 111 | 1996 | |
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| 5,483,954 Inhaler and medicated package | 22 | 1994 | |
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| 5,724,959 Powder inhaler with specific orifice and baffle arrangement | 34 | 1994 | |
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| 5,039,280 Pump assembly for obtaining a high vacuum | 21 | 1990 | |
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| 5,881,719 Inhaler for administering medicaments from blister packs | 58 | 1996 | |
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| 5,284,133 Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means | 198 | 1992 | |
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| 4,907,583 Device in powder inhalators | 131 | 1988 | |
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| 4,955,371 Disposable inhalation activated, aerosol device for pulmonary medicine | 72 | 1989 | |
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| 5,435,301 Powder inhaler having dispersing, discharge, and dwell-time chambers, along with an acceleration channel | 36 | 1993 | |
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| 5,617,845 Inhalation device free from propellent gas | 32 | 1994 | |
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| 5,975,076 Dry powder inhalers | 22 | 1996 | |
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| 4,274,404 Oxygen supply system controlled by user exhalation | 32 | 1979 | |
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| 5,896,853 Controlled flow inhalers | 11 | 1997 | |
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| 4,558,710 Testing of the airways and pulmonary tract of a patient, particularly for sensitivity to aerosols | 146 | 1984 | |
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| 5,727,546 Powder inhaler with breath flow regulation valve | 49 | 1996 | |
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| 5,161,524 Dosage inhalator with air flow velocity regulating means | 159 | 1991 | |
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| 6,065,472 Multidose powder inhalation device | 55 | 1998 | |
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| 4,533,137 Pulmonary training method | 85 | 1984 | |
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| 5,040,527 Metered dose inhalation unit with slide means | 40 | 1990 | |
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| 6,055,979 Dosing and discharging device for flowable media including powder/air dispersions | 14 | 1997 | |
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| 5,184,641 Flow regulator | 17 | 1991 | |
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| 4,484,577 Drug delivery method and inhalation device therefor | 142 | 1982 | |
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| 5,301,666 Powder inhaler | 80 | 1992 | |
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| 5,042,472 Powder inhaler device | 58 | 1990 | |
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| 6,142,146 Inhalation device | 56 | 1998 | |
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| 4,495,944 Inhalation therapy apparatus | 35 | 1983 | |
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| 6,076,523 Oxygen blending in a piston ventilator | 41 | 1998 | |
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| 6,102,036 Breath activated inhaler | 133 | 1998 | |
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| 5,447,150 Medicament dispensing device | 94 | 1993 | |
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| 5,993,421 Medicament dispenser | 18 | 1997 | |
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| 4,442,856 Oxygen regulator and alarm system for an anesthesia machine | 33 | 1981 | |
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| 6,116,237 Methods of dry powder inhalation | 41 | 1997 | |
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| 5,813,401 Nebulizer automatic control valve | 22 | 1996 | |
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| 5,069,204 Inhaler | 113 | 1990 | |
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| 5,529,059 Inhalation devices | 31 | 1994 | |
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| 4,259,951 Dual valve for respiratory device | 69 | 1979 | |
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| 6,095,134 Methods and apparatus for fine particle formation | 151 | 1997 | |
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| 5,042,467 Medication inhaler with fitting having a sonic signalling device | 60 | 1990 | |
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| 4,677,975 Method of dispensing and/or a dispenser | 296 | 1985 | |
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| 5,447,151 Powder inhaler with suction actuated locking means | 69 | 1993 | |
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| 5,385,140 Aerosol inhalation device | 48 | 1993 | |
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| 4,391,283 Incentive spirometer | 24 | 1981 | |
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| 6,116,239 Inhalation device | 28 | 1998 | |
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| 4,284,083 Inhalation incentive device | 12 | 1979 | |
| 4,338,931 Device for the quick inhalation of drugs in powder form by humans suffering from asthma | 81 | 1980 | |
| 4,444,202 Breathing exerciser | 27 | 1982 | |
| 4,592,348 Aerosol inhaler | 56 | 1984 | |
| 5,201,308 Powder inhaler | 85 | 1992 | |
| 5,655,520 Flexible valve for administering constant flow rates of medicine from a nebulizer | 118 | 1993 | |
| 5,522,380 Metered dose medication adaptor with improved incentive spirometer | 38 | 1995 | |
| 5,513,630 Powder dispenser | 16 | 1995 | |
| 5,568,807 Air-flow control for an inhaler | 15 | 1995 | |
| 5,542,412 Powder Dispenser | 29 | 1995 | |
| 5,653,223 Accurately controlled portable nebulizer | 15 | 1995 | |
| 5,699,789 Dry powder inhaler | 36 | 1996 | |
| 6,070,573 Flexible valve for administering constant flow rates of medicine from a nebulizer | 11 | 1997 | |
| 5,855,202 Aerosol holding chamber for a metered-dose inhaler | 37 | 1997 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Sep 6, 2014 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Sep 6, 2018 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |