Process for the synthesis of oligomeric compounds

United States of America Patent

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Mar 6, 2007
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Aug 18, 2005
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Dec 28, 2004
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Feb 4, 1999

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Abstract

Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.

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Patent Owner	Address
IONIS PHARMACEUTICALS INC	2855 GAZELLE COURT CARLSBAD CA 90210

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C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....

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Inventor Name	Address	# of filed Patents	Total Citations
Capaldi, Daniel C	Carlsbad, CA	25	390
Cole, Douglas L	Half Moon Bay, CA	192	1362
Guzaev, Andrei P	Vista, CA	26	703
Krotz, Achim	San Diego, CA	11	395
Manoharan, Muthiah	Weston, MA	491	18658
Ravikumar, Vasulinga	Carlsbad, CA	38	486

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Process for the synthesis of oligomeric compounds

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United States of America Patent

11025791

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PATENT NO	7186822
APP PUB NO	20050182251A1
SERIAL NO	11025791
DOCKET NO

US Family Size	Non-US Coverage
Patent Longevity	Forward Citations

DATE PUBLISHED	PUBLICATION/PATENT NO.	PUBLICATION TYPE
March 06, 2007	US,7186822,B2 US7186822B2	GRANTED PATENT AS SECOND PUBLICATION
August 18, 2005	US,20050182251,A1 US20050182251A1	FIRST PUBLISHED PATENT APPLICATION

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11025791

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