Method of preparing intermediates useful in synthesis of retroviral protease inhibitors
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United States of America Patent
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Mar 13, 2007
Grant Date -
Aug 4, 2005
app pub date -
Oct 13, 2004
filing date -
Nov 19, 1990
priority date (Note) -
Expired
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Abstract
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide from a chiral alpha amino aldehyde.
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