Scorpion peptide as hypotensive agent
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United States of America Patent
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Mar 20, 2007
Grant Date -
Jan 19, 2006
app pub date -
Jun 9, 2003
filing date -
Jun 7, 2002
priority date (Note) -
Expired
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Abstract
The present invention provides isoformes from a peptide family belonging to South American scorpion Tityus serrulatus that acts as hypotensive agents by potentiating Bradykinin and, therefore, can be used as anti-hypertensive drugs. A peptide was firstly isolated from Tityus serrulatus venom and showed a strong and long-lasted hypotensive activity when tested in rats. This peptide was first named TsHpt-I (Tityus serrulatus Hypotensin-I). Also, three more highly similar isoformes were identified and revealed a peptide family with very close primary structure. They were named TsHpt-II, TsHpt-III and TsHpt-IV.
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