Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
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United States of America Patent
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Mar 27, 2007
Grant Date -
Feb 26, 2004
app pub date -
Mar 5, 2003
filing date -
Sep 7, 2001
priority date (Note) -
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Abstract
Pharmaceutical compositions that include insulin, an insulin drug-oligomer conjugate, a fatty acid component, and a bile salt component or a bile salt component without a fatty acid component are described. The insulin drug is covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component, when together, can be present in a weight-to-weight ratio of between 1:15 and 15:1. Methods of treating an insulin deficiency in a subject in need of such treatment using such pharmaceutical compositions are also provided, as are methods of providing such pharmaceutical compositions.
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