Polyketides and their synthesis
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United States of America Patent
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Apr 3, 2007
Grant Date -
Apr 28, 2005
app pub date -
Feb 19, 2004
filing date -
Jun 29, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A polyketide synthase ('PKS') of Type I is a complex multienzyme including a loading domain linked to a multiplicity of extension domains. The first extension module receives an acyl starter unit from the loading domain and each extension module adds a further ketide unit which may undergo processing (e.g. reduction). We have found that the Ksq domain possessed by some PKS's has decarboxylating activity, e.g. generating (substituted) acyl from (substituted) malonyl. The CLF domain of type II PKS's has similar activity. By inserting loading modules including such domains into PKS's not normally possessing them it is possible to control the starter units used.
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