Optically similar reference samples
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United States of America Patent
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-
Apr 10, 2007
Grant Date -
Apr 29, 2004
app pub date -
Oct 28, 2002
filing date -
Apr 11, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Systems and methods for establishing and/or maintaining the accuracy of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to reduce the effect of instrument or environment variation on the measurement capability of the model. The optically similar reference can be a gel composition having scattering particles suspended therein. The reference gel can be directly applied to a spectroscopic instrument sampler, or can be in a container specifically designed for optimal coupling to a spectroscopic instrument.
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