Antibodies to non-shed Muc1 and Muc16, and uses thereof
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United States of America Patent
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Apr 10, 2007
Grant Date -
Mar 25, 2004
app pub date -
Jul 3, 2003
filing date -
Jul 3, 2002
priority date (Note) -
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Abstract
The present invention relates to antibodies, antibody fragments, conjugates of antibodies and antibody fragments with cytotoxic agents, and hybridomas producing the antibodies and antibody fragments, where the antibodies and antibody fragments recognize extracellular epitopes of plasma membrane proteins that are not released into the extracellular fluid, and to methods for the detection, monitoring and treatment of malignancies such as breast cancer and ovarian cancer using the antibodies, antibody fragments and conjugates.
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