Fret protease assays for botulinum serotype A/E toxins
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United States of America Patent
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Apr 24, 2007
Grant Date -
Jul 31, 2003
app pub date -
Aug 28, 2001
filing date -
Aug 28, 2001
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Abstract
The present invention provides clostridial toxin substrates useful in assaying for the protease activity of any clostridial toxin, including botulinum toxins of all serotypes as well as tetanus toxins. A clostridial toxin substrate of the invention contains a donor fluorophore; an acceptor having an absorbance spectrum overlapping the emission spectrum of the donor fluorophore; and a clostridial toxin recognition sequence that includes a cleavage site, where the cleavage site intervenes between the donor fluorophore and the acceptor and where, under the appropriate conditions, resonance energy transfer is exhibited between the donor fluorophore and the acceptor.
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