Genes involved in polyketide synthase pathways and uses thereof
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United States of America Patent
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Apr 24, 2007
Grant Date -
Jan 20, 2005
app pub date -
Jul 15, 2003
filing date -
Jul 15, 2003
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Abstract
The subject invention relates to isolated nucleic acid sequences or genes involved in polyketide synthase (PKS) biosynthetic pathways. In particular, such pathways are involved in the production of polyunsaturated fatty acids (PUFAs) such as, for example, Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). Specifically, the invention relates to isolating nucleic acid sequences encoding proteins involved in eukaryotic PUFA-PKS systems and to uses of these genes and encoded proteins in PUFA-PKS systems, in heterologous hosts, for the production of PUFAs such as EPA and DHA.
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