Crystals of LuxP and complexes thereof
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United States of America Patent
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Apr 24, 2007
Grant Date -
Sep 18, 2003
app pub date -
Aug 22, 2002
filing date -
Aug 24, 2001
priority date (Note) -
Expired
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Abstract
A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.
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