Methods of decreasing the accumulation of extracellular matrix associated with glomerulonephritis with anti-TGF-.beta.-specific antibodies
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United States of America Patent
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May 8, 2007
Issued Date -
N/A
app pub date -
Dec 2, 1994
filing date -
Sep 29, 1989
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Expired
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Abstract
The present invention provides a method for treating or arresting the progress of pathologies characterized by an accumulation of extracellular matrix components by providing an agent to suppress the activity of transforming growth factor .beta. (TGF-.beta.) a peptide growth factor which is anabolic and leads to fibrosis and angiogenesis. In one embodiment, such agent is anti-TGF-.beta. antibody. Pathologies which can be so treated include, but are not limited to, glomerulonephritis, adult respiratory distress syndrome and cirrhosis of the liver. The invention further provides a method for the diagnosis of pathologies, or incipient pathologies, which are characterized by the accumulation of extracellular matrix components in tissues by determining the levels of TGF-.beta. in the tissues, a high level being indicative of such pathologies.
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