Composite particles, derived conjugates, preparation method and applications
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United States of America Patent
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May 15, 2007
Grant Date -
Jun 17, 2004
app pub date -
May 6, 2002
filing date -
May 10, 2001
priority date (Note) -
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Abstract
The invention relates to composite particles comprising a hydrophobic polymer core and inorganic nanoparticles. Said hydrophobic polymer forms a polymer matrix inside which the inorganic nanoparticles are stabilized and distributed in a relatively homogenous manner. Said particles are at least partially surrounded by an amphophilic copolymer comprising a hydrophobic part and a hydrophilic part, said hydrophobic part being at least partially immobilized in the polymer matrix. The inventor also relates to the preparation method thereof, the conjugates comprising such particles and a ligand and the use of same in reactants and therapeutic compositions.
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